در این مقاله علمی از ژورنال Frontiers چاپ 2019 اثر RNase کایمریک خاص بر مقاومت آنتی بیوتیکی بررسی شده است. دراین مقاله از محیط LB کمپانی Condalab استفاده شده است.
متن کامل مقاله:
Testing a Human Antimicrobial RNase Chimera Against Bacterial Resistance
Guillem Prats-Ejarque, Jiarui Li†, Fatima Ait-Ichou†, Helena Lorente and Ester Boix*
- Faculty of Biosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
The emergence of bacterial resistance to the most commonly used antibiotics encourages the design of novel antimicrobial drugs. Antimicrobial proteins and peptides (AMPs) are the key players in host innate immunity. They exert a rapid and multifaceted action that reduces the development of bacterial adaptation mechanisms. Human antimicrobial RNases belonging to the vertebrate specific RNase A superfamily participate in the maintenance of tissue and body fluid sterility. Among the eight human canonical RNases, RNase 3 stands out as the most cationic and effective bactericidal protein against Gram-ne
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